Page 1 of 2 12 LastLast
Results 1 to 10 of 15

Thread: Abstract of study on low dose naltrexone

  1. #1
    Distinguished Community Member Lazarus's Avatar
    Join Date
    Oct 2006
    Location
    western MA
    Posts
    990

    Default Abstract of study on low dose naltrexone

    Clin Rheumatol. 2014 Feb 15. [Epub ahead of print]
    The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain.
    Younger J, Parkitny L, McLain D.
    Author information

    Abstract
    Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn's disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial cells. These effects may be unique to low dosages of naltrexone and appear to be entirely independent from naltrexone's better-known activity on opioid receptors. As a daily oral therapy, LDN is inexpensive and well-tolerated. Despite initial promise of efficacy, the use of LDN for chronic disorders is still highly experimental. Published trials have low sample sizes, and few replications have been performed. We cover the typical usage of LDN in clinical trials, caveats to using the medication, and recommendations for future research and clinical work. LDN may represent one of the first glial cell modulators to be used for the management of chronic pain disorders.
    PMID: 24526250 [PubMed - as supplied by publisher]
    LinkOut - more resources

    PubMed Commons home
    PubMed Commons

    0 comments
    Linda~~~~

    Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"

  2. #2
    Distinguished Community Member Jeanie Z's Avatar
    Join Date
    Dec 2006
    Location
    WPB,FL
    Posts
    1,372

    Smile

    :) Hi everyone. Linda I have been on 4.5 mg of LDN nightly for 14 years. I wish all MSers would try it.

    A few MSers I know who are on LDN had symptom improvement, some of several symptoms and as long as they have stayed on LDN the symptoms did not come back. I had no symptom inprovement but I have not progressed any further than I was when I began it. That is good enough for me as I had frequent new symptoms before LDN and none since using it. Jeanie :)


    https://m.facebook.com/photo.php?fbi...9857&source=46
    Last edited by Jeanie Z; 02-17-2014 at 10:44 AM.

  3. The following user says "thanks"


  4. #3
    Distinguished Community Member Cherie's Avatar
    Join Date
    Oct 2006
    Location
    Southeastern NE
    Posts
    1,268

    Default

    I have been on it since August. Went off for a couple of weeks when I was trying to figure if it was worsening sleep disorder, then back on until three weeks ago. I cannot saw that I say any improvement or stabilization on it and feel no differently off it. That said, I am improving as far as symptoms left over from last March's relapse. I attribute that to being back on an Interferon since October.

  5. The following 2 users say "thanks"


  6. #4
    Distinguished Community Member SalpalSally's Avatar
    Join Date
    Oct 2006
    Location
    SWOhio
    Posts
    3,569

    Default

    I'm only on LDN for 11 yrs now, so I'm sure, that I feel better because of the LDN!!

    And thanks Jeanie, that info is so good to know.
    Last edited by SalpalSally; 02-17-2014 at 07:46 PM.
    Love, Sally


    "The best way out is always through". Robert Frost







  7. The following 2 users say "thanks"


  8. #5
    Distinguished Community Member SalpalSally's Avatar
    Join Date
    Oct 2006
    Location
    SWOhio
    Posts
    3,569

    Default

    Does anyone know, what ever happened to LarryLDN?
    Haven't seen that little stinker for years.
    Love, Sally


    "The best way out is always through". Robert Frost







  9. The following user says "thanks"


  10. #6
    Distinguished Community Member agate's Avatar
    Join Date
    Oct 2006
    Location
    USA
    Posts
    6,714
    Blog Entries
    11

    Default

    Quote Originally Posted by SalpalSally View Post
    This quote is hidden because you are ignoring this member. Show Quote
    Does anyone know, what ever happened to LarryLDN?
    Haven't seen that little stinker for years.
    He's logged in just now. I happened to notice, and then I saw your post.

    Maybe now that he's been revealed, he'll say a few words. Many people here must remember him.
    Last edited by agate; 02-18-2014 at 05:55 PM.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

  11. The following 2 users say "thanks"


  12. #7
    New Community Member LarryLDN's Avatar
    Join Date
    Oct 2006
    Location
    Fort Myers, FL
    Posts
    10

    Default

    Quote Originally Posted by SalpalSally View Post
    This quote is hidden because you are ignoring this member. Show Quote
    Does anyone know, what ever happened to LarryLDN?
    Haven't seen that little stinker for years.
    8 years? 4 years?

    Life as I knew it ended 1st 2/06, I had my last cigarette 2 months later, 4/26/2006. 2 years later my career ended, on the 5th anniversary of LDN, 4/17/08. 2 months later, the divorce was decreed. After an unbelievably awesome 2009 (not medically, in spite of), I ended up in Florida for 6 weeks ending with buying a condo, to be near my dad since LDN saved his life in 3/2007. I moved to Florida 3/10.



    As for just the LDN, after finding out in 2007 that all my food allergies disappeared (from 1972 & 2003, pre-LDN), I had the tests redone in 2009 to confirm. After moving to Florida, the following year, 5/11, I had an allergist run the tests again. Still 0 food allergies. Chocolate was the biggie; to be able to eat chocolate again is amazing.

    MRI's as noted in http://www.larrygc.com/mystory I had one in 4/2007 showing no progression, but still the same bad lesion load from 2002-3, and then another in 4/2008 pretty much confirming the stability but clearly MS. AND.... 5 years later.... I had an MRI in 7/2013 that "except for showing age" they see NO Progression from previous MRI.




    As far as Symptoms, my lesion load hasn't changed, hasn't Improved at all, therefore I still am Suffering with the same issues from the initial improvements.


    On LDN we can have an awesomely running immune system, whatever else you may have going on, it may have nothing to o with. NO Colds or FLU or ALLERGIES, much improved bladder vs pre-LDN (still a slave to it a lot), and still the hair & nails growth hasn't slowed any. I started shaving my head 4/09 and still do.

    Last year I had some foot pain & they also thought a brace for my left foot could help with the MS... It does.. but it also helps with the foot pain. So I can walk better with it, plus the foot pain is also alleviated.



    Oh, still on 3.0



    There ya go... still kicking

  13. The following 2 users say "thanks"


  14. #8
    Distinguished Community Member SalpalSally's Avatar
    Join Date
    Oct 2006
    Location
    SWOhio
    Posts
    3,569

    Default

    Hello Larry, come on in. How are you doing?
    Love, Sally


    "The best way out is always through". Robert Frost







  15. The following 2 users say "thanks"


  16. #9
    Distinguished Community Member agate's Avatar
    Join Date
    Oct 2006
    Location
    USA
    Posts
    6,714
    Blog Entries
    11

    Default

    Well, at least we know he's still among the survivors, and that's good.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

  17. The following user says "thanks"


  18. #10
    New Community Member LarryLDN's Avatar
    Join Date
    Oct 2006
    Location
    Fort Myers, FL
    Posts
    10

    Default

    Survivors. Yep

  19. The following user says "thanks"


Page 1 of 2 12 LastLast

Similar Threads

  1. Replies: 3
    Last Post: 02-23-2013, 10:09 AM
  2. Replies: 11
    Last Post: 10-15-2012, 03:36 PM
  3. Age and disability accumulation in MS (PubMed abstract)
    By agate in forum Multiple Sclerosis
    Replies: 7
    Last Post: 09-17-2011, 04:55 PM
  4. LDN (low dose naltrexone) How Does It Work?
    By SalpalSally in forum Multiple Sclerosis
    Replies: 7
    Last Post: 09-13-2011, 07:35 PM
  5. There Is No Safe Dose of Prions
    By flatfish in forum Creutzfeldt Jakobs Disease (CJD)
    Replies: 0
    Last Post: 08-26-2011, 08:17 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  


BTC Inc's Disclaimer and Privacy Policy

The material on this site is for information & support purposes only, and is not a substitute for medical advice provided by a licensed health care provider. Always consult your doctor before trying anything that you find online.