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Thread: Bone-marrow transplant treatment for very aggressive MS?

  1. #1
    Distinguished Community Member agate's Avatar
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    Default Bone-marrow transplant treatment for very aggressive MS?

    Some researchers in Ottawa have come up with what they're hoping is an effective treatment for very aggressive MS. It has its risks but looks promising. (Thanks to Jeanie and Cherie for calling attention to this.)

    Excerpt from an article in the Ottawa Citizen (April 3, 2014) about it:

    Quote
    The [researchers] originally set out to monitor the development of the disease and find a way to treat it. Their theory was this: Wipe out the entire immune system, reboot it with a transplant of the patientís own bone marrow and wait for MS to regenerate.



    The article can be seen here.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

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    Distinguished Community Member SalpalSally's Avatar
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    I'd move to Canada right now, if I had the aggressive type of MS.
    I wonder why we haven't heard more about this.? Of course, if I
    had had this type of MS, I probably wouldn't have made it to 73
    yrs old.

    Thanks for posting, Agate.
    Love, Sally


    "The best way out is always through". Robert Frost







  3. #3
    Distinguished Community Member agate's Avatar
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    I wonder why we haven't heard more about this.?
    Sally, I'm just guessing here but researchers in general respect only peer-reviewed articles, and these researchers are publishing in Annals of Neurology, which isn't on the AAAS list of peer-reviewed scientific journals.

    Odd since it's the official journal of the American Academy of Neurology, but they abandoned traditional peer-review some years ago.

    Again, this is just a guess.
    Last edited by agate; 01-16-2014 at 08:02 AM.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

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    Distinguished Community Member Howie's Avatar
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    Cool

    Thanks Agate. For some reason, this seems like old news, like 10+ years. I'm pretty sure.
    Last edited by Howie; 01-16-2014 at 10:54 AM.
    Roswell was a gift.

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    Distinguished Community Member SalpalSally's Avatar
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    I think the operation is old news Howie, but not the wonderful
    100% success rate. That's news to me!!!!
    Love, Sally


    "The best way out is always through". Robert Frost







  6. #6
    Distinguished Community Member agate's Avatar
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    Quote Originally Posted by Howie View Post
    This quote is hidden because you are ignoring this member. Show Quote
    Thanks Agate. For some reason, this seems like old news, like 10+ years. I'm pretty sure it was for MS. Perhaps now, they see it only to be tried for very aggressive MS.
    Nothing wrong with Howie's memory! A memory like a sponge, maybe?

    According to the article, work began on this "about 13 years ago." Here's another version of the story:

    http://www.ms-uk.org/bonemarrow

    And it's a small study. With only 24 people involved, 100% might not be very meaningful. It looks as if the last 13 years have been spent going through phases of the study, and now it's reaching the point where new results might be forthcoming.
    Last edited by agate; 01-16-2014 at 10:43 AM.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

  7. #7
    Distinguished Community Member Howie's Avatar
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    I can't delete.
    Last edited by Howie; 01-16-2014 at 10:58 AM.
    Roswell was a gift.

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    Distinguished Community Member Frog42's Avatar
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    I know just how you feel, Howie. I've had that happen and it drove me crazy(er)!


    Whatever happens around you, don't take it personally. Nothing other people do is because of you. It is because of themselves. -- Miguel Ruiz

  9. #9
    Distinguished Community Member Howie's Avatar
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    Cool

    It seems like I've deleted posts here before. I guess those holes on my MRI really do mean something's missing.
    Roswell was a gift.

  10. #10
    Distinguished Community Member Cherie's Avatar
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    It is an old and long term small study that has been multi country. And results do look good. But it has only been used on people with very aggressive forms of MS who do not respond to therapy and decline rapidly. I spoke with Dr. Freedman about this three years ago at CMSC in San Antonio and he alluded to in in a presentation he did in Boston that was only open to MS Drs and Nurses about 5 years ago. Not cheap. And since there are so many effective therapies now available that are less costly than a couple of months in a hospital isolation setting to destroy marrow then replace it, it has not moved into main stream very quickly (my opinion as to the rate of speed)

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