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Thread: Still taking Gilenia

  1. #1

    Default Still taking Gilenia

    Noticed couple posts concerning injection sites as well as Copaxone. I've been taking the once a day pill named Gilenia for about a year and love not having to shoot the MS drug every week or day. I haven't experienced any problems, (side effects.)

    if your doc and insurance can swing it, give it a try.

    Ya Can't Argue With An Idiot

  2. #2
    Distinguished Community Member agate's Avatar
    Join Date
    Oct 2006
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    Don't know if you saw this:

    From Medical News Today, July 19, 2013:

    Drug Approved For MS Shows Promise For Preventing Heart Failure

    A drug already approved to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy, or thickening of the cardiac muscle - a disorder that often leads to heart failure, researchers at the University of Illinois at Chicago College of Medicine report.

    The findings are published in the journal Circulation: Heart Failure.

    Cardiac hypertrophy is a slow thickening of the heart muscle that shrinks the interior volume of the heart, forcing the organ to work harder to pump a diminishing volume of blood.

    "There comes a day when the heart just can't keep up any more, and it fails," says R. John Solaro, UIC distinguished university professor and head of physiology and biophysics.

    Cardiac hypertrophy, which afflicts one in 500 people, can be caused by high blood pressure or inherited through genes that control contraction of the heart.

    Solaro and his colleagues believe that if the thickening of the heart muscle could be slowed, or maybe even reversed, heart failure could be prevented.

    Solaro and his UIC colleague Yunbo Ke, research assistant professor of physiology and biophysics, were interested in a chemical derived from a fungus used in traditional Chinese medicine as an eternal-youth nostrum. That compound, designated FTY-720, has been developed into a drug to treat multiple sclerosis and is a chemical cousin to the drug most widely used to suppress the immune system and prevent organ rejection in transplant patients.

    The substance, Solaro said, "mimics certain lipids in the body that play a role in the development of cardiac hypertrophy."

    Using an experimental mouse model of cardiac hypertrophy, Solaro and his team found that FTY-720 significantly reduced heart mass; lessened fibrosis, or stiffening of the heart muscle; and improved overall cardiac function in the mice that received the drug.

    The researchers also showed that the drug inhibits expression of several genes involved in cardiac hypertrophy.

    "We saw that FTY-720 blocked the activity of a protein we know is involved in causing heart-cell thickening," said Solaro. When that protein is blocked, he said, collagen and other proteins involved in heart-cell thickening are also down-regulated.

    Collagen, a fibrous protein found between heart cells, causes the heart muscle to become stiff. Collagen is often overabundant in people with cardiac hypertrophy.

    "When the heart muscle is stiff, it actually takes effort to relax the heart and allow blood to flow into the ventricles, so this is another way this disease causes the heart to work harder than it should have to," Solaro said.

    "FTY-720 is a potential therapy to treat this disease and prevent heart failure for people where the disease is acquired through high blood pressure, and possibly inherited hypertrophy as well," he said.


    The study was supported in part by NIH grants PO1 HL 062426 and RO1 HL 064035; grant G10002647 from the Medical Research Council of Great Britain; and UICís Center for Clinical and Translational Science grant UL1RR029879.

    University of Illinois at Chicago
    MS, diagnosed 1980. Avonex 2001-2004. Copaxone 2006-2009.

  3. #3
    Distinguished Community Member Cherie's Avatar
    Join Date
    Oct 2006


    Glad it's working well for you. I've heard this from a number of people (more than either of the other two orals currently available). However, there is a group of people with cardiac problems that cannot take it. People need to be screened before asking their doc for a script (or the doc needs to screen them before writing the script). Are you having liver enzymes checked regularly? Do you notice any adverse side effects and were they worse at the beginning than they are now? Really want to know.

  4. #4



    Yes, doc checks liver. So far, so good. I did know about the possible danger for heart patients before beginning the protocol. Signed a waiver. I do have specific issues with the health of my heart. At this stage of life, think it's a fair bet.

    Ya Can't Argue With An Idiot

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