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Thread: Discovery May Lead to New Treatment for ALS

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  1. #1
    Community Member Prot's Avatar
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    Default Discovery May Lead to New Treatment for ALS

    Researchers at Oregon Health & Science University School of Dentistry have discovered that TDP-43, a protein strongly linked to ALS (amyotrophic lateral sclerosis) and other neurodegenerative diseases, appears to activate a variety of different molecular pathways when genetically manipulated. The findings have implications for understanding and possibly treating ALS and neurodegenerative diseases such as Alzheimer's and Parkinson's.

    ALS affects two in 100,000 adults in the United States annually and the prognosis for patients is grim.The new discovery is published online in G3: Genes, Genomes, Genetics (and the July 2012 print issue of G3).

    Using a fruit fly model, the OHSU team genetically increased or eliminated TDP-43 to study its effect on the central nervous system. By using massively parallel sequencing methods to profile the expression of genes in the central nervous system, the team found that the loss of TDP-43 results in widespread gene activation and altered splicing, much of which is reversed by rescue of TDP-43 expression. Although previous studies have implicated both absence and over expression of TDP-43 in ALS, the OHSU study showed little overlap in the gene expression between these two manipulations, suggesting that the bulk of the genes affected are different.

    "Our data suggest that TDP-43 plays a role in synaptic transmission, synaptic release and endocytosis," said Dennis Hazelett, Ph.D., lead author of the study. "We also uncovered a potential novel regulation of several pathways, many targets of which appear to be conserved."


    http://www.sciencedaily.com/releases...0718172402.htm
    Yet inside there is this perpetual nagging doubt;
    the feeling we are possessed by a 'subtle lack of togetherness''.

  2. #2
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    Prot, the link to the website is not working. Would you be so kind as to double check? My husband is being tested with ALS as a possible diagnosis.

    Gabriella
    Last edited by Gabriella7; 07-21-2012 at 10:48 AM.
    Progressive/Relapsing MS, Myasthenia Gravis, Spinal Stenosis, Degenerative Disc Disease, Diabetes, Hypertension, Hashimoto's Thyroiditis
    Advocate for ADA, Artist's Community for Change, ADAPT, Universal Living in Place, HopeKeepers, Complementary and Alternative Medicine

    "Life is mostly froth and bubble, two things stand like stone. Kindness in another's trouble, Courage in your own"........Adam Lindsay Gordon

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    Administrator/SYSOP Mike Weins's Avatar
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    It works for me Gabriella. Very interesting article.
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  4. #4
    Distinguished Community Member Earth Mother 2 Angels's Avatar
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    Default Link Worked for Me

    ((((((Gabriella))))))

    Here is the link again:


    http://www.sciencedaily.com/releases...0718172402.htm


    To copy and paste, use http://www.

    followed by

    sciencedaily.com/releases/2012/07/120718172402.htm

    OR

    Go to http://www.sciencedaily.com

    and use the Search on their site. Type ALS in the search box. Several articles are listed.

    This article's date is July 18, 2012.

    Hope this helps you.

    Love & Light,

    Rose
    Mom to Jon, 48, (seizure disorder; Gtube; trache; colostomy; osteoporosis; hypothyroid; enlarged prostate; lymphedema, assorted mysteries) and Michael, 32, (intractable seizures; Gtube), who were born with an undiagnosed progressive neuromuscular disease and courageous spirits. Our Angel Michael received his wings in 2003 and now resides in Heaven. Our Angel Jon lives at home with me and Jim, the world's most wonderful dad.

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    Thanks for the links, the clitch must have been on my end. I'll read all of the articles tomorrow when I am rested.

    Gabriella
    Progressive/Relapsing MS, Myasthenia Gravis, Spinal Stenosis, Degenerative Disc Disease, Diabetes, Hypertension, Hashimoto's Thyroiditis
    Advocate for ADA, Artist's Community for Change, ADAPT, Universal Living in Place, HopeKeepers, Complementary and Alternative Medicine

    "Life is mostly froth and bubble, two things stand like stone. Kindness in another's trouble, Courage in your own"........Adam Lindsay Gordon

  6. #6
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    Gabriella, if you happen to come back by please go to the MS forum and read what I wrote about the VA (if your husband happens to have served at anytime in the military). It could be something of importance to you. It is under your ALS thread.

    Virginia
    Virginia

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