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Thread: (Abstract) Adverse event profile differences between Rituxan and Ocrevus...

  1. #1
    Distinguished Community Member agate's Avatar
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    Default (Abstract) Adverse event profile differences between Rituxan and Ocrevus...

    Here's another boring abstract but I'd like to know. Are the authors saying that there are probably more infections resulting from taking Ocrevus than from Rituxan?

    Or are they saying that the methods for reporting adverse events for the two drugs are different and the results may be skewed so that the infection rate looks higher for Ocrevus than for Rituxan (but might not really be higher)?

    From Multiple Sclerosis Journal (August 24, 2020)--"Adverse event profile differences between rituximab and ocrelizumab: Findings from the FDA Adverse Event Reporting Database":

    https://journals.sagepub.com/doi/abs...52458520949986
    Last edited by agate; 08-25-2020 at 07:55 AM. Reason: adding article title
    MS, diagnosed 1980. Avonex 2001-2004. Copaxone 2006-2009.

    "Always put off until tomorrow whatever you think you should do today." --Anonymous



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    I got the impression they were saying Ocrevus causes more infections because it depletes B cells more than Rituxan.

    I am not good at reading these things, but some others on here probably are.
    Virginia

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    Distinguished Community Member agate's Avatar
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    Sometimes medical abstracts and articles are carelessly written. This one strikes me as ambiguous but the authors may have intended to be a bit mealymouthed about their findings because they're just not sure what's going on here--whether the adverse event reporting system varies from one drug to another or whether there really is quite a difference between infections related to Rituxan and infections related to Ocrevus.

    I think you're right, and they're saying that if there is a real difference, then the difference in B cell depletion might be the cause.
    MS, diagnosed 1980. Avonex 2001-2004. Copaxone 2006-2009.

    "Always put off until tomorrow whatever you think you should do today." --Anonymous



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    Werenít there more cancer incidents on Ocrevus vs Rituxan too?

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    Distinguished Community Member agate's Avatar
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    Maybe this is what you're thinking of, Sunshine? (See paragraph 4.)

    https://journals.sagepub.com/doi/ful...52458518757930

    The difference in infection rates strikes me as considerable, for the abstract about infections states:

    Ocrelizumab was associated with an almost two times higher frequency of infections than rituximab (21.93% vs 11.05%, respectively).
    Last edited by agate; 08-25-2020 at 10:51 AM.
    MS, diagnosed 1980. Avonex 2001-2004. Copaxone 2006-2009.

    "Always put off until tomorrow whatever you think you should do today." --Anonymous



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    Distinguished Community Member Lazarus's Avatar
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    Quote Originally Posted by Sunshine 2 View Post
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    Weren’t there more cancer incidents on Ocrevus vs Rituxan too?
    You are correct Sunshine. Because there is a slightly greater risk of cancer with Ocrevus I stay on rituxan. My cancer history lets me stay on the drug I prefer. Rituxan is older, better tolerated and less expensive. Although both drugs have little danger.
    Linda~~~~

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    Distinguished Community Member Lazarus's Avatar
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    Quote Originally Posted by Sunshine 2 View Post
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    Werenít there more cancer incidents on Ocrevus vs Rituxan too?
    You are correct Sunshine. Because there is a slightly greater risk of cancer with Ocrevus I stay on rituxan. My cancer history lets me stay on the drug I prefer. Rituxan is older, better tolerated and less expensive. Although both drugs have little danger.
    Linda~~~~

    Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"

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    Like Linda, that is why I decided to stay on Rituxan. My neurologist has patients on both drugs, though.

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    Distinguished Community Member agate's Avatar
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    Now I'm confused. Multiple Sclerosis News Today (August 26) has an article indicating that the article in the MS Journal (link to abstract in post #1 in this thread) finds that the cancer risk is greater for Rituxan than for Ocrevus. It must be in the article itself but it's not mentioned in the abstract.

    https://multiplesclerosisnewstoday.c...ting-database/
    MS, diagnosed 1980. Avonex 2001-2004. Copaxone 2006-2009.

    "Always put off until tomorrow whatever you think you should do today." --Anonymous



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    Everything about this disease is confusing, but I am reading it the same way you are Agate. As far as I can tell Rituxan has quite a bit higher risk of cancer than Ocrevus, almost 3 times. It also has higher risk of immune related problems about two times. However Ocrevus has higher risk of infections especially urinary infections.
    Virginia

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