Results 1 to 7 of 7

Thread: Here’s a study on riruximab...posted but Dave in Active MSers site

  1. #1
    Distinguished Community Member Lazarus's Avatar
    Join Date
    Oct 2006
    Location
    western MA
    Posts
    1,774

    Default Here’s a study on riruximab...posted but Dave in Active MSers site

    Here's a just-released study... -D

    Treatment of multiple sclerosis with rituximab: A multicentric Italian–Swiss experience

    Chiara Zecca*, Francesca Bovis*, Giovanni Novi, et al.

    First Published October 1, 2019 Research Article
    https://doi.org/10.1177/1352458519872889

    Abstract

    Background:
    Rituximab, an anti-CD20 monoclonal antibody leading to B lymphocyte depletion, is increasingly used as an off-label treatment option for multiple sclerosis (MS).

    Objective:
    To investigate the effectiveness and safety of rituximab in relapsing–remitting (RR) and progressive MS.

    Methods:
    This is a multicenter, retrospective study on consecutive MS patients treated off-label with rituximab in 22 Italian and 1 Swiss MS centers. Relapse rate, time to first relapse, Expanded Disability Status Scale (EDSS) progression, incidence of adverse events, and radiological outcomes from 2009 to 2019 were analyzed.

    Results:
    A total of 355/451 enrolled subjects had at least one follow-up visit and were included in the outcome analysis. Annualized relapse rate significantly decreases after rituximab initiation versus the pre-rituximab start year in RRMS (from 0.86 to 0.09, p < .0001) and in secondary-progressive (SP) MS (from 0.34 to 0.06, p < .0001) and had a slight decrease in primary-progressive (PP) MS patients (from 0.12 to 0.07, p = 0.45). After 3 years from rituximab start, the proportion of patients with a confirmed EDSS progression was 14.6% in the RRMS group, 24.7% in the SPMS group, and 41.5% in the PPMS group. No major safety concerns arose.

    Conclusion:
    Consistently with other observational studies, our data show effectiveness of rituximab in reducing disease activity in patients with MS.
    __________________
    Dave Bexfield
    ActiveMSers
    Linda~~~~

    Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"

  2. The following 5 users say "thanks"


  3. #2
    Distinguished Community Member Sunshine's Avatar
    Join Date
    Oct 2006
    Posts
    5,443

    Default

    Good numbers Laz.

    Wish it was head to head with Ocrevus.

  4. The following 2 users say "thanks"


  5. #3
    Distinguished Community Member Lazarus's Avatar
    Join Date
    Oct 2006
    Location
    western MA
    Posts
    1,774

    Default

    Quote Originally Posted by Sunshine View Post
    This quote is hidden because you are ignoring this member. Show Quote
    Good numbers Laz.

    Wish it was head to head with Ocrevus.
    .? Head to head? Not sure what you mean..... I am glad you had some relief with Ativan.

    Busy day today finishing picking crops and loading for tomorrow’s market. All finished now. Time to start resting until alarm at 3:45 am
    Linda~~~~

    Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"

  6. The following 5 users say "thanks"


  7. #4
    Distinguished Community Member
    Join Date
    Oct 2006
    Location
    Midwest USA
    Posts
    699

    Default

    Linda, I THINK Sunshine may mean a comparison with Ocrevus???

  8. The following 4 users say "thanks"


  9. #5
    Distinguished Community Member Lazarus's Avatar
    Join Date
    Oct 2006
    Location
    western MA
    Posts
    1,774

    Default

    Oh...thanks Parsi.
    I think Dr. Volmer uses the terms interchangeably. The idea was that the drug company tweeted the mix because its patent on rituximab was running out.
    Linda~~~~

    Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"

  10. The following 4 users say "thanks"


  11. #6
    Distinguished Community Member Sunshine's Avatar
    Join Date
    Oct 2006
    Posts
    5,443

    Default

    Yes, I meant comparison of Rituximab with Ocrevus.

    And yes, Ocrevus is a sneaky Pharma maneuver around the patent running out on Rituximab.

  12. The following 3 users say "thanks"


  13. #7
    Distinguished Community Member agate's Avatar
    Join Date
    Oct 2006
    Location
    USA
    Posts
    9,313
    Blog Entries
    29

    Default

    There was this recently (at the annual ECTRIMS conference)--"ECTRIMS2019: Is Rituximab a Reasonable Option for MS Patients?":

    https://multiplesclerosisnewstoday.c...r-ms-patients/
    Last edited by agate; 10-12-2019 at 08:09 AM.
    MS, diagnosed 1980. Avonex 2001-2004. Copaxone 2006-2009.

  14. The following 3 users say "thanks"


Similar Threads

  1. Diet and MS... study report I copied from Active MSers site.
    By Lazarus in forum Multiple Sclerosis
    Replies: 3
    Last Post: 09-06-2019, 01:15 PM
  2. Replies: 6
    Last Post: 10-11-2018, 10:45 AM
  3. Replies: 3
    Last Post: 01-11-2018, 01:12 PM
  4. This is ACTIVE MSers newsletter that I got today...
    By Lazarus in forum Multiple Sclerosis
    Replies: 1
    Last Post: 11-07-2017, 02:59 AM
  5. Replies: 9
    Last Post: 08-16-2014, 10:18 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  


BTC Inc's Disclaimer and Privacy Policy

The material on this site is for information & support purposes only, and is not a substitute for medical advice provided by a licensed health care provider. Always consult your doctor before trying anything that you find online.