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Thread: Something interesting to read about inflammation inhibiting myelin repair

  1. #1
    Distinguished Community Member Lazarus's Avatar
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    Default Something interesting to read about inflammation inhibiting myelin repair

    Inflammation Can Hijack Brain Repair Cells to Ramp Up Immune Attacks in MS, Researchers Report
    September 4, 2019

    SUMMARY
    Johns Hopkins researchers and collaborators have traced abnormal activity of immature brain cells called “OPCs,” which normally spring into action to repair nerve-insulating myelin after it is damaged by immune system attacks in MS.
    The team reports that under inflammatory conditions such as what occurs in MS, the OPCs can be hijacked to act as immune helpers that can ramp up damage to myelin and suppress myelin repair.
    Understanding this new finding may lead to new ways to protect the nervous system and resume normal repair mechanisms in people with MS.
    The team, funded in part by the National MS Society, published its findings on August 29, 2019 in Nature Communications: volume 10, Article number: 3887 (2019).

    DETAILS
    Background: Multiple sclerosis involves immune system attacks on the myelin sheath that supports and protects nerve fibers and facilitates nerve signaling in the brain and spinal cord. The brain has natural capacity to repair myelin, and this is facilitated by resident immature cells (oligodendrocyte precursor cells – OPCs) that normally spring into action when damage occurs, maturing into myelin-making cells capable of restoring lost myelin. This process can stall in MS, leaving the underlying nerve fibers vulnerable to damage and loss.

    The Study: Researchers at Johns Hopkins University, including Drs. Leslie Kirby and Peter Calabresi, and other collaborators conducted a series of studies aimed at determining why myelin repair can be stalled in MS. They found that in a mouse model, inflammatory factors such as immune messenger chemicals and immune cells can inhibit OPCs from maturing into myelin-making cells. Under these inflammatory conditions, OPCs were also co-opted to become immune helpers (antigen-presenting cells) that could ramp up immune-mediated damage to myelin. The team also confirmed that in MS brain lesions in postmortem MS tissues, OPCs showed similar signs of being co-opted.

    Conclusions: This study offers new insights into mechanisms that may underlie the inadequate myelin repair that occurs in MS, and opens up new possibilities for finding ways to reduce ongoing inflammation and restore myelin.

    The team, funded in part by the National MS Society, published its findings on August 29, 2019 in Nature Communications: volume 10, Article number: 3887 (2019). The open-access paper can be read by anyone.

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    About research on nervous system repair
    About Multiple Sclerosis

    Multiple sclerosis is an unpredictable, often disabling disease of the central nervous system that disrupts the flow of information within the brain, and between the brain and body. Symptoms range from numbness and tingling to blindness and paralysis. The progress, severity and specific symptoms of MS in any one person cannot yet be predicted, but advances in research and treatment are leading to better understanding and moving us closer to a world free of MS. Most people with MS are diagnosed between the ages of 20 and 50, with at least two to three times more women than men being diagnosed with the disease. MS affects more than 2.3 million people worldwide.

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    Linda~~~~

    Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"

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    Thanks Linda, interesting to read. I am always happy to hear that maybe, just maybe younger people might be spared what some of us older ones now know.
    Virginia

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    Distinguished Community Member Sunshine's Avatar
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    Thanks LAZ! I look forward to pursuing this article when I get back from todays doc appt :)

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    Distinguished Community Member Lazarus's Avatar
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    Quote Originally Posted by Virginia View Post
    This quote is hidden because you are ignoring this member. Show Quote
    Thanks Linda, interesting to read. I am always happy to hear that maybe, just maybe younger people might be spared what some of us older ones now know.
    Ha! I am 72 now...and John is 82! How did that happen? I just blinked and went from 35 to 72!

    I saw my relatively new neurologist yesterday...I have been seeing her for about 2 years as my old one retired from seeing patients but is still in the hospital doing research....and the appointment went great. Lasted for an hour and I never felt rushed. ( just like with my old one).
    Linda~~~~

    Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"

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    Linda, so good to hear something like that. When my old Neurologist left, who I had had since he diagnosed me, and I got a new one the first two appointments went well and I liked the new one. Since then I am lucky to get 5 minutes. However, I haven't had anything near an hour since sometime before my old Neurologist left. I miss not feeling rushed.
    Virginia

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