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Thread: Experts: Yes, chronic wasting disease in deer is a public health issue — for people

  1. #1
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    Exclamation Experts: Yes, chronic wasting disease in deer is a public health issue — for people

    SATURDAY, FEBRUARY 09, 2019

    Experts: Yes, chronic wasting disease in deer is a public health issue — for people

    https://chronic-wasting-disease.blog...isease-in.html


    kind regards, terry

  2. #2
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    Sheep and cattle may be exposed to CWD via common grazing areas with affected deer but so far, appear to be poorly susceptible to mule deer CWD (Sigurdson, 2008). In contrast, cattle are highly susceptible to white-tailed deer CWD and mule deer CWD in experimental conditions but no natural CWD infections in cattle have been reported (Sigurdson, 2008; Hamir et al., 2006). It is not known how susceptible humans are to CWD but given that the prion can be present in muscle, it is likely that humans have been exposed to the agent via consumption of venison (Sigurdson, 2008). Initial experimental research suggests that human susceptibility to CWD is low and there may be a robust species barrier for CWD transmission to humans (Sigurdson, 2008), however the risk appetite for a public health threat may still find this level unacceptable.

    https://assets.publishing.service.go...une2018_v1.pdf

    http://chronic-wasting-disease.blogs...-agent-of.html

    cwd scrapie pigs oral routes

    ***> However, at 51 months of incubation or greater, 5 animals were positive by one or more diagnostic methods. Furthermore, positive bioassay results were obtained from all inoculated groups (oral and intracranial; market weight and end of study) suggesting that swine are potential hosts for the agent of scrapie. <***

    >*** Although the current U.S. feed ban is based on keeping tissues from TSE infected cattle from contaminating animal feed, swine rations in the U.S. could contain animal derived components including materials from scrapie infected sheep and goats. These results indicating the susceptibility of pigs to sheep scrapie, coupled with the limitations of the current feed ban, indicates that a revision of the feed ban may be necessary to protect swine production and potentially human health. <***

    ***> Results: PrPSc was not detected by EIA and IHC in any RPLNs. All tonsils and MLNs were negative by IHC, though the MLN from one pig in the oral <6 month group was positive by EIA. PrPSc was detected by QuIC in at least one of the lymphoid tissues examined in 5/6 pigs in the intracranial <6 months group, 6/7 intracranial >6 months group, 5/6 pigs in the oral <6 months group, and 4/6 oral >6 months group. Overall, the MLN was positive in 14/19 (74%) of samples examined, the RPLN in 8/18 (44%), and the tonsil in 10/25 (40%).

    ***> Conclusions: This study demonstrates that PrPSc accumulates in lymphoid tissues from pigs challenged intracranially or orally with the CWD agent, and can be detected as early as 4 months after challenge. CWD-infected pigs rarely develop clinical disease and if they do, they do so after a long incubation period.

    This raises the possibility that CWD-infected pigs could shed prions into their environment long before they develop clinical disease.

    Furthermore, lymphoid tissues from CWD-infected pigs could present a potential source of CWD infectivity in the animal and human food chains.

    https://www.ars.usda.gov/research/pu...eqNo115=353091

    https://www.ars.usda.gov/research/pr...432011&fy=2017

    https://www.ars.usda.gov/research/pu...eqNo115=337105

    TUESDAY, APRIL 18, 2017

    *** EXTREME USA FDA PART 589 TSE PRION FEED LOOP HOLE STILL EXIST, AND PRICE OF POKER GOES UP ***

    http://usdameatexport.blogspot.com/2...rion-feed.html

    ***> Wednesday, January 23, 2019

    ***> CFIA SFCR Guidance on Specified risk material (SRM) came into force on January 15, 2019 <***

    https://specifiedriskmaterial.blogsp...fied-risk.html

    hay, straw, grains...and cwd tse prion

    ***> NORWAY CWD UPDATE December 2018 Report from the Norwegian Scientific Committee for Food and Environment (VKM) 2018: 16

    Factors that can contribute to spread of CWD – an update on the situation in Nordfjella, Norway

    Opinion of Panel on biological hazards of the Norwegian Scientific Committee for Food and Environment 13.12.2018 ISBN: 978-82-8259-316-8 ISSN: 2535-4019 Norwegian Scientific Committee for Food and Environment (VKM) Po 222 Skψyen 0213 Oslo Norway FRIDAY, DECEMBER 14, 2018 Norway, Nordfjella VKM 2018 16

    Factors that can contribute to spread of CWD TSE Prion UPDATE December 14, 2018

    https://vkm.no/download/18.696229a71...ead%202018.pdf

    https://chronic-wasting-disease.blog...6-factors.html

    THURSDAY, OCTOBER 25, 2018

    ***> Norway New additional requirements for imports of hay and straw for animal feed from countries outside the EEA due to CWD TSE Prion

    https://www.mattilsynet.no/dyr_og_dy..._dyrefor.32299

    https://chronic-wasting-disease.blog...ments-for.html

    THURSDAY, FEBRUARY 14, 2019

    Norway Eradication of Chronic Wasting Disease is not completed

    https://chronic-wasting-disease.blog...c-wasting.html

    Saturday, December 15, 2018

    ***> ADRD Summit RFI Singeltary COMMENT SUBMISSION BSE, SCRAPIE, CWD, AND HUMAN TSE PRION DISEASE December 14, 2018

    https://prionprp.blogspot.com/2018/1...y-comment.html

    MONDAY, JANUARY 21, 2019

    Bovine Spongiform Encephalopathy BSE TSE Prion Surveillance FDA USDA APHIS FSIS UPDATE 2019

    https://bovineprp.blogspot.com/2019/...pathy-bse.html

    Wednesday, January 23, 2019

    CFIA SFCR Guidance on Specified risk material (SRM) came into force on January 15, 2019

    https://specifiedriskmaterial.blogsp...fied-risk.html


    Terry S. Singeltary Sr.

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