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Thread: Pretreating Ocrevus patients w/antihistamines and liquids to lower infusion reactions

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    Distinguished Community Member agate's Avatar
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    Default Pretreating Ocrevus patients w/antihistamines and liquids to lower infusion reactions

    Some researchers have found that pretreating MS patients taking Ocrevus with antihistamines and fluids lowered infusion reactions by 60%, as reported in Multiple Sclerosis News Today (December 18):
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    https://multiplesclerosisnewstoday.com/2018/12/18/pretreating-ms-patients-with-new-protocol-lowers-infusion-reactions-to-ocrevus-study-reports/?utm_source=Multiple+Sclerosis&utm_campaign=975c5e a29d-RSS_US_EMAIL_CAMPAIGN&utm_medium=email&utm_term=0_ b5fb7a3dae-975c5ea29d-71286581
    i don't trip--I do random gravity checks.

    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

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    Distinguished Community Member Lazarus's Avatar
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    Pretreatments are standard procedure for my rituxan infusions..I think for everyone...
    Sunshine gets them for IVIg, I think I remember her discussing that. I know I did. The pretreatment s I get are some kind of antihistamine, some steroid and some pain med.

    During one IVIg infusion when my nurse forgot to give me the premeds there was a dramatic situation and the infusion was stopped for an hour until the all clear.

    Drinking water before infusions is really important or my nurses have trouble finding a vein to use. When I am hydrated there is no problem but when I do not drink enough water before I get there...big problem. The water probably makes a difference besides this too.

    It is amazing how important the 3 premeds and water are and I have been doing infusions for about 15 years if not more.

    Thanks for the article. With so many people starting Ocrevus it is important for the patients to be almost more informed than the nurses and doctors!
    Last edited by Lazarus; 12-23-2018 at 04:28 AM.
    Linda~~~~

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    Distinguished Community Member Cherie's Avatar
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    I always get 650 mg Tylenol, 25 mg benadryl and my doc wanted 100 mg Solucortef but I refuse the steroid. I only had a reaction the first infusion that needed more benadryl but none since then.

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    Distinguished Community Member Sunshine's Avatar
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    I never pretreated before IVIG until My last infusion two weeks ago since the one prior to it created massive leg spasms and halted the IVIG for an hour while infused Ativan could calm it down.

    So, now I will pretreat with oral 1mg Ativan and a second tab after 5 hours.

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    Distinguished Community Member Lazarus's Avatar
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    Quote Originally Posted by Sunshine View Post
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    I never pretreated before IVIG until My last infusion two weeks ago since the one prior to it created massive leg spasms and halted the IVIG for an hour while infused Ativan could calm it down.

    So, now I will pretreat with oral 1mg Ativan and a second tab after 5 hours.
    Hmmm..that’s interesting. It would be worth asking about the difference between the 2 protocols we followed relating to pretreatment.
    Linda~~~~

    Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"

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