Results 1 to 1 of 1

Thread: Lipoic Acid Study

  1. #1
    Distinguished Community Member SuzE-Q's Avatar
    Join Date
    Nov 2006

    Default Lipoic Acid Study

    Complement Ther Med. 2018 Dec;41:169-174.

    doi: 10.1016/j.ctim.2018.09.006. Epub 2018 Sep 22.

    Effects of lipoic acid on walking performance, gait, and balance in secondary progressive multiple sclerosis.

    Loy BD1, Fling BW2, Horak FB3, Bourdette DN4, Spain RI4.

    Gait and balance impairment is common in secondary progressive multiple sclerosis (SPMS). Lipoic acid (LA), an over-the-counter antioxidant, is effective in MS animal models and may improve walking speed, but effects on mobility are unreported.

    Examine the effects of 1200 mg daily oral dose of LA versus placebo (PLA) on gait and balance in a 2-year, randomized, double-blind pilot study.

    134 participants were screened for eligibility before assignment to LA (n = 28) or PLA (n = 26). Included here were, 21 participants with SPMS who took LA (N = 11) or PLA (N = 10) capsules for 2 years (enrolled May 2, 2011 - August 14, 2015) and completed all tasks without the use of an assistive device. Participants completed the Timed Up and Go (TUG) and quiet standing tasks every 6 months while wearing inertial sensors (APDM Opals) to quantify mobility.

    LA had a medium effect on time to complete TUG at 2 years (g = 0.51; 95% CI = -0.35, 1.38). In a subset of 18 participants with less disability (EDSS < 6, no use of ambulatory device), turning time was significantly shorter with LA (p =  0.048, Δ= 0.48 s). No differences in balance metrics were found between groups.

    LA had an effect on walking performance in people with SPMS, particularly in those with lower baseline disability.

  2. The following 4 users say "thanks"

Similar Threads

  1. Lipoic acid?
    By agate in forum Multiple Sclerosis
    Replies: 9
    Last Post: 10-25-2018, 12:18 PM
  2. Alpha Lipoic acid outperformed Ocrevus
    By Sunshine in forum Multiple Sclerosis
    Replies: 15
    Last Post: 10-22-2017, 12:15 PM
  3. Lipoic acid a possible treatment for SPMS?
    By agate in forum Multiple Sclerosis
    Replies: 7
    Last Post: 12-06-2016, 11:51 AM
  4. SDR study in people with CP
    By funnylegs4 in forum Cerebral Palsy
    Replies: 0
    Last Post: 11-06-2013, 10:12 PM
  5. Replies: 5
    Last Post: 10-11-2013, 01:53 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts

BTC Inc's Disclaimer and Privacy Policy

The material on this site is for information & support purposes only, and is not a substitute for medical advice provided by a licensed health care provider. Always consult your doctor before trying anything that you find online.