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Thread: A new variant of Creutzfeldt-Jakob disease in the UK 1995 revisited 2018 a review

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    Exclamation A new variant of Creutzfeldt-Jakob disease in the UK 1995 revisited 2018 a review

    WEDNESDAY, SEPTEMBER 26, 2018

    A new variant of Creutzfeldt-Jakob disease in the UK 1995 revisited 2018 a review of science

    http://creutzfeldt-jakob-disease.blo...ldt-jakob.html

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    this link has been updated to include...see;

    WEDNESDAY, MARCH 15, 2017

    Clinical and laboratory features of 14 young Chinese probable sCJD patients Clinical and laboratory features of 14 young Chinese probable sCJD patients

    Qi Shi, Kang Xiao, Cao Chen, Wei Zhou, Chen Gao, Jing Wang,

    Page 00 | Received 02 Nov 2016, Accepted 20 Jan 2017, Accepted author version posted online: 09 Mar 2017

    Download citation http://dx.doi.org/10.1080/19336896.2017.1287656

    Full Article Figures & data References Citations Metrics Reprints & Permissions Get access Accepted author version

    Abstract

    Sporadic Creutzfeldt-Jakob disease (sCJD) occurs frequently in the relatively older population, mainly in the groups of 60–69 and 70–79 year-old. Since 2006 when China carried out national CJD surveillance, 14 young probable sCJD patients below 40 year-old were identified, counting for 1.93% of all probable sCJD cases. The clinical features of young probable sCJD cases, including the onset feature, the presence of sCJD-associated signs and the clinical duration, are indistinguishable from those of older patients. Special sCJD-associated abnormalities on EEG and MRI were noticed in 7 and 10 cases. CSF 14-3-3 was positive in 7 cases. CSF RT-QuIC showed positive reactive curves in 9 cases, with short lag phases. PRNP sequencing did not find any mutation. Due to low rate of brain autopsy in China, performances of other CJD-associated examinations as much as possible are extremely important for the distinguish diagnosis of young probable sCJD patients.

    Key words: Creutzfeldt-Jakob disease, sporadic, prion disease, young patient, surveillance Disclaimer

    As a service to authors and researchers we are providing this version of an accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to these versions also.

    http://www.tandfonline.com/doi/full/...eedAccess=true
    Quality evaluation for the surveillance system of human prion diseases in China based on the data from 2010 to 2016

    Qi Shi, Wei Zhou, Cao Chen, Chen Gao, Kang Xiao, Jing Wang, show all Pages 484-491 | Received 07 Jul 2016, Accepted 22 Aug 2016, Accepted author version posted online: 03 Oct 2016, Published online: 03 Oct 2016 Download citation

    http://dx.doi.org/10.1080/19336896.2016.1229731

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    ABSTRACT

    The surveillance of CJD or human prion diseases (PrDs) has been conducted for 10 y in China. To evaluate the quality of China CJD surveillance system, the collections of the clinical and epidemiological information, the sampling, the clinical examinations and laboratory tests and follow-up survey were separately analyzed based on the data from 2010 to 2015. The obtaining rates of clinical-information table, epidemiological-information table, sample inspection sheet and medical record of the referring patients from reporting units to the center of CJD surveillance maintained or reached at very high levels, being close to 100% in the past 3 y. 93.82%, 85.23%, 96.21% and 94.70% of the reported cases had the data of MRI, EEG, CSF 14-3-3 and PRNP sequencing, respectively. Follow-up surveys were conducted in about 50% cases in 2010 and 2011, 93.39% cases in 2012 and 100% cases in the last 3 y. High obtaining rates of the clinical and epidemiological data, high conducting rates of the relevant clinical examinations and laboratory tests, high performing rates of follow-up survey for every referring case reflect a good implemental capacity in China CJD surveillance system, which supplies solid basis for recognition and diagnosis of human prion diseases and guarantees good quality of China CJD surveillance system.

    KEYWORDS: Creutzfeldt-Jakob disease, evaluation, human prion diseases, surveillance, quality

    http://tandfonline.com/doi/abs/10.10...6.2016.1229731

    WEDNESDAY, OCTOBER 22, 2008

    Surveillance for Creutzfeldt-Jakob disease in China from 2006 to 2007 Research article

    Surveillance for Creutzfeldt-Jakob disease in China from 2006 to 2007

    Qi Shi , Chen Gao , Wei Zhou , Baoyun Zhang , Jianming Chen , Chan Tian , Huiying Jiang , Jun Han , Nijuan Xiang , Xiaofang Wang , Yongjun Gao and Xiaoping Dong

    BMC Public Health 2008, 8:360doi:10.1186/1471-2458-8-360

    Published: 18 October 2008

    Abstract (provisional) Background Human transmissible spongiform encephalopathies (HTSE), or Creutzfeldt-Jakob disease (CJD), is a group of rare and fatal diseases in central nervous system. Since outbreak of bovine spongiform encephalopathy (BSE) and variant CJD, a worldwide CJD surveillance network has been established under the proposition of WHO. In China, a national CJD surveillance system has started since 2002. The data of CJD surveillance from 2006 to 2007 was analyzed.

    Methods Total 12 provinces are included in CJD surveillance system. The surveillance unit in each province consists of one or two sentinel hospitals and the provincial CDC. All suspected CJD cases reported from CJD surveillance were diagnosed and subtyped based on the diagnostic criteria for CJD issued by WHO.

    Results Total 192 suspected CJD cases were reported and 5 genetic CJD, 51 probable and 30 possible sporadic CJD (sCJD) cases were diagnosed. The collected sCJD cases distribute sporadically without geographical clustering and seasonal relativity and the highest incidences in both probable and possible sCJD cases appeared in the group of 60-69 year. The most common three foremost symptoms were progressive dementia, cerebellum and mental-related symptoms. The probable sCJD patients owning both typical EEG alteration and CSF protein 14-3-3 positive have more characteristic clinical syndromes than the ones having only one positive. The polymorphisms of codon 129 of all tested reported cases shows typical patterns of Han Chinese as previous reports, that M129M are predominant whereas M129V are seldom.

    Conclusion Chinese CJD patients possessed similar epidemiological and clinical characteristics as worldwide.

    http://www.biomedcentral.com/1471-2458/8/360/abstract

    http://www.biomedcentral.com/content...2458-8-360.pdf

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    Voluntary Report - public distribution

    Date: 3/27/2007

    GAIN Report Number: CH7025

    CH7025

    China, Peoples Republic of

    Livestock and Products

    China Proposes to Ease Certification Requirements for Cosmetics Imports

    2007

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    kind regards, terry

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