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Thread: Debate on rituximab vs. ocrelizumab (Rituxan vs. Ocrevus) in MS Journal

  1. #11
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  3. #12
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    Why do they do Rituxon two weeks apart. Is it a half dose like the Ocrevus first time?
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    Quote Originally Posted by ssusan View Post
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    Why do they do Rituxon two weeks apart. Is it a half dose like the Ocrevus first time?
    What is the Ocrevus dose? Then what is the rituxan dose? Do they determine dose by the patient’s weight so that we all get different doses?
    I have never heard the words about half dose applied to any of my rituxan infusions. I just know that it is the standard protocol that is used for rituxan infusions for all my friends on rituxan here or at the MS clinic where Ionete is. Good question for her!
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  7. #14
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    Let me try it this way, why is the protocol for Rituxon twice two weeks apart and then every six months.Ocrevus is once every six months. Everyone gets the same dose 600 mg
    I think Rituxon is the same ramping up the rate

    I can’t find the Rituxon doseage
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  9. #15
    Distinguished Community Member agate's Avatar
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    This article is from 2016 but might help:

    It was a trial but this was the dosage regimen:

    Patients were usually treated with single infusions of 500 or 1,000 mg rituximab IV every 6–12 months, in some cases after an initial higher dose treatment course (1,000–2,000 mg subdivided into 2 infusions given within 1 month).
    Also there is this in the article:


    RITUXIMAB DOSING.The 2 most common rituximab protocols in Sweden are 500 and 1,000 mg every 6 months as single maintenance doses after an initial dose that may vary from 500 to 2,000 mg, sometimes divided into 2 infusions within 1 month. To compare these 2 treatment regimens, we subdivided the RRMS cohort into those who had received ≤750 mg/infusion and those who had received >750 mg/infusion as maintenance dose.
    Sounds to me as if some people got the higher dose at first, which was subdivided into two doses within a month, but why some people got that higher dose isn't clear to me.
    Last edited by agate; 08-08-2018 at 02:50 PM.
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  11. #16
    Distinguished Community Member agate's Avatar
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    Ocrelizumab (Ocrevus) dosing--this is from a .pdf file from the Ocrevus Website.

    Recommended dose and dose administration

    • The initial 600 mg dose is administered as 2 separate intravenous infusions given over approximately 2.5 hours:first as a 300 mg intravenous infusion followed 2 weeks later by a second 300 mg intravenous infusion*

    • Subsequent doses are administered over approximately 3.5 hours as a single 600 mg intravenous infusionevery 6 months*

    • Observe the patient for at least 1 hour after the completion of the infusion

    Single infusionDoses of OCREVUSmust be separated by atleast 5 months.

    Delayed or missed doses

    • If a planned infusion of OCREVUS is missed, administer OCREVUS as soon as possible; do not waituntil the next scheduled dose• Reset the dose schedule to administer the next sequential dose 6 months after the missed doseis administered

    *Infusion time may take longer if the infusion is interrupted or slowed
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
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  13. #17
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    Thanks , Agate. Rituxon dose can vary. Ocrevous iDose always the same.

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