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Thread: I know...this exciting research will not bring much hope to us oldies but......

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    Distinguished Community Member Lazarus's Avatar
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    Default I know...this exciting research will not bring much hope to us oldies but......

    July 27, 2018
    New research offers insight into how drugs can repair damaged brain cells that cause disability in patients with multiple sclerosis. The study suggests a target for new drugs that may lead to myelin regeneration treatments for people with MS.

    In the current study, researchers at Case Western Reserve University School of Medicine demonstrated that miconazole enhanced myelin formation by inhibiting an enzyme used by brain stem cells to produce cholesterol. Subsequent experiments identified more than 20 new drugs that enhance myelin formation by inhibiting closely-related cholesterol-producing enzymes. Drugs identified previously by labs across the world as enhancing new myelin were also found to inhibit these same enzymes.

    Results of mouse model studies sometimes do not translate to humans. Clinical candidates based on this work are not expected to enter clinical trials until 2019. However, the authors said the new understanding of myelin repair provides a promising new path toward novel, regenerative MS treatments.

    The findings were published in the journal Nature.
    Linda~~~~

    Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"

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    Distinguished Community Member Sunshine's Avatar
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    Miconizole— isn’t that an ingredient in Monistat anti yeast infection cream??

    Very interesting research. Why wouldn’t it help us oldsters?

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    Also, if our cholesterol is much lower would that help us to have an easier course?
    Virginia

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    Distinguished Community Member Lazarus's Avatar
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    Quote Originally Posted by Virginia View Post
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    Also, if our cholesterol is much lower would that help us to have an easier course?
    That is the question I had
    Linda~~~~

    Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"

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    Distinguished Community Member Sunshine's Avatar
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    Swank proposed a diet high in sat fat causes flare ups

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    Distinguished Community Member Cherie's Avatar
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    The clinical trials so far in this method of repair are very selective in who responds. Seems to be mostly men and mostly those who have had MS for fewer than 10 years. It cannot work, however unless the inflammation in the CNS is totally quieted as any inflammation tends to damage myelin so the repair process cannot begin till inflammation is gone.

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