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Thread: Cancer and GAD65 and Stiff Person Syndrome

  1. #1
    Distinguished Community Member Sunshine's Avatar
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    Default Cancer and GAD65 and Stiff Person Syndrome

    http://www.healthylivingmagazine.us/Articles/11108/

    Cancers can elevate GAD65.unsure why Mayo didnít rec PET scan to detect hidden cancer. Will ask when I have my ducks in order.

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  3. #2
    Distinguished Community Member Sunshine's Avatar
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    3% of the general population has elevated GAD65

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  5. #3
    Distinguished Community Member Sunshine's Avatar
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    Antibodies associated with cancer and elevated GAD65 due to paraneoplastic Syndrome are “Hu, Yo, Ri, CRMP5, antiphysin, Ma2 and Tr”

    Will ask doc about running those tests.

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    Distinguished Community Member Sunshine's Avatar
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    Acta Neurol Scand Suppl. 2011;(191):83-8. doi: 10.1111/j.1600-0404.2011.01549.x.
    Onconeural antibodies in patients with neurological symptoms: detection and clinical significance.

    Raspotnig M1, Vedeler CA, Storstein A.

    Abstract

    BACKGROUND:
    Onconeural antibodies are strongly associated with cancer and paraneoplastic neurological syndromes (PNS). Most of these antibodies are well-characterized (antibodies against Hu, Yo, Ri, CRMP5, amphiphysin, Ma2 and Tr) and are in common use for the diagnosis of definite PNS.

    MATERIALS AND METHODS:
    Literature on detection and clinical significance of onconeural antibodies were identified by using relevant search terms in PubMed and reviewed.

    CONCLUSIONS:
    The onconeural antibodies are directed against intracellular antigens and their pathogenic role is still largely unknown. They are highly specific markers of paraneoplastic aetiology in patients with neurological symptoms. Detection of an onconeural antibody in a patient with neurological symptoms should lead to prompt investigation for cancer.

    However, absence of detectable onconeural antibodies does not exclude the PNS diagnosis .In particular, failure to detect antibodies in patients without classical PNS symptoms may result in less vigorous cancer screening and diagnostic delay. Neuronal antibodies that are directed to synaptic proteins or proteins of the cell membrane are also associated with neurological symptoms, and probably have pathogenic effects. The association between these antibodies and cancer is less robust, and they are usually not included among the onconeural antibodies.

    © 2011 John Wiley & Sons A/S.
    Last edited by Sunshine; 04-22-2018 at 07:24 AM.

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