Page 3 of 3 FirstFirst 123
Results 21 to 26 of 26

Thread: Facts about Stiff Person Syndrome

  1. #21
    Distinguished Community Member Sunshine's Avatar
    Join Date
    Oct 2006
    Posts
    2,801

    Default

    Fact #13

    There are 5 types of Stiff Person Syndrome:

    -classic stiff person syndrome
    -focal stiff person syndrome
    -jerking stiff person syndrome—scribblesdizzle has this type (see her post above)
    -progressive encephalomyelitis with rigidity and myoclonus (PERM)
    -paraneoplastic-related stiff person syndrome

  2. #22
    Distinguished Community Member Sunshine's Avatar
    Join Date
    Oct 2006
    Posts
    2,801

    Default

    Fact #14

    According to raresiseases.org


    There are classes of medications that should be avoided in SPS, including serotonin-norepinephrine reuptake inhibitors (SNRIs; i.e, tricyclic antidepressants and duloxetine) and opioids. SNRIs have previously been shown to worsen the EMG activity and clinical symptoms in SPS. Opioids are not recommended for pain control because most individuals with SPS are on benzodiazepines. Mixing these two classes of medications can lead to severe respiratory depression and death.

  3. #23
    Distinguished Community Member Sunshine's Avatar
    Join Date
    Oct 2006
    Posts
    2,801

    Default

    Fact #15

    It’s thought that Stiff Person Syndrome is caused by the immune system producing antibodies to a protein called GAD. GAD is necessary to synthesize GABA. GABA is necessary to control muscle movement and to inhibit excitability in the brain and spinal cord.

    This means people with SPS will have rigid muscles and spasms. They will also find themselves working harder to inhibit emotional outbursts. They will startle in an obvious way, often experiencing stiffness or severe spasms in response to a stimulation that may almost go unnoticed, or at least rapidly accommodated to by others.

  4. The following user says "thanks"


  5. #24
    Distinguished Community Member Sunshine's Avatar
    Join Date
    Oct 2006
    Posts
    2,801

    Default

    Fact #16

    There is a case study showing that medical marijuana (Sativex) can alleviate some Stiff Person Syndrome symptoms:

    http://ejhp.bmj.com/content/19/2/219.2

  6. The following user says "thanks"


  7. #25
    Distinguished Community Member Sunshine's Avatar
    Join Date
    Oct 2006
    Posts
    2,801

    Default

    Fact #17

    Most, but not all, of patients with Stiff Person Syndrome have elevated GAD65 levels in the blood indicates that the body is creating an antibody that attacks GAD, impairing the body’s ability to make GABA.

    However, Some people with stiff person syndrome have antibodies to amphiphysin, which is a protein involved in the transmission of signals from one neuron to another. People with these antibodies have a higher risk for developing breast, lung, or colon cancer.

  8. The following user says "thanks"


  9. #26
    Distinguished Community Member Sunshine's Avatar
    Join Date
    Oct 2006
    Posts
    2,801

    Default

    Fact #18

    Both Type 1 Diabetes and Stiff Person Syndrome are autoimmune disorders with elevated GAD in serum. But the GAD in SPS is 10-1,000 fold higher than in Type 1 Diabetes,.

    A large number of people with SPS, about 35%, do have, or go on to develop Type 1 Diabetes.
    Last edited by Sunshine; Yesterday at 09:38 AM.

Page 3 of 3 FirstFirst 123

Similar Threads

  1. Stiff Person Syndrome
    By Sunshine in forum Stiff Person Syndrome
    Replies: 6
    Last Post: 02-06-2018, 03:50 AM
  2. Imposter syndrome and Stiff Person Syndrome
    By Sunshine in forum Stiff Person Syndrome
    Replies: 0
    Last Post: 01-26-2018, 06:28 AM
  3. Stiff Person Syndrome
    By Sunshine in forum Multiple Sclerosis
    Replies: 4
    Last Post: 01-07-2018, 04:58 PM
  4. Causes of Stiff Person Syndrome
    By Sunshine in forum Stiff Person Syndrome
    Replies: 2
    Last Post: 01-06-2018, 01:47 PM
  5. Stiff Person Syndrome
    By Sunshine in forum Stiff Person Syndrome
    Replies: 0
    Last Post: 01-06-2018, 06:03 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  


BTC Inc's Disclaimer and Privacy Policy

The material on this site is for information & support purposes only, and is not a substitute for medical advice provided by a licensed health care provider. Always consult your doctor before trying anything that you find online.