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Thread: On Biotin.... Biotin recommended by Howard Weiner at UMass MS clinic near Boston

  1. #1
    Distinguished Community Member Lazarus's Avatar
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    Default On Biotin.... Biotin recommended by Howard Weiner at UMass MS clinic near Boston

    Howard Weiner, M.D., Director of Partner's MS Center at Brigham and Women's Hospital as recommended a 100 mg dose of Biotin taken three times a day (for a total of 300 mg) citing results of the pilot study below (#2). I don't know if this is a general recommendation he is giving to all progressive patients---I did not ask---but I have no reason to think that my SPMS is in anyway unusual or different from others. For further information see

    1. “Remyelination Therapy in Multiple Sclerosis”

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674562/

    Front Neurol. 2015; 6: 257.

    Published online 2015 Dec 10. doi: 10.3389/fneur.2015.00257

    PMCID: PMC4674562



    2. “High doses of biotin in chronic progressive multiple sclerosis: a pilot study”

    https://www.ncbi.nlm.nih.gov/pubmed/25787192

    Mult Scler Relat Disord. 2015 Mar;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. Epub 2015 Jan 24.


    3. “Intersections of pathways involving biotin and iron relative to therapeutic mechanisms for progressive multiple sclerosis”

    https://www.ncbi.nlm.nih.gov/pubmed/28147220

    Discov Med. 2016 Dec;22(123):381-387.



    4. “Metabolic pathways as possible therapeutic targets for progressive multiple sclerosis“

    https://www.ncbi.nlm.nih.gov/pubmed/28966637

    Neural Regen Res. 2017 Aug;12(8):1262-1267. doi: 10.4103/1673-5374.213542.



    Biotin is available through Johnson Compounding and Wellness Center

    http://www.naturalcompounder.com/?s=
    Linda~~~~

    Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"

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  3. #2
    Distinguished Community Member agate's Avatar
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    Is this the recommendation from Dr. Weiner?

    https://www.healthline.com/health-ne...iple-sclerosis

    Sounds as if he's really keen on it--though the cost seems to be high ($150/month).
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

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  5. #3
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    There is a board on Facebook on Biotin. You have to join the group. Lots of good info and people's experiences. Linda, there isa member of your support group who has been on it for a few months. She also does Rituxon .
    My neuro at MS clinic in Worcester has mentioned it several times for fatigue.
    Be the person your dog thinks you are

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    Distinguished Community Member BBS1951's Avatar
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    My Neuro had me on it. I bought the pure Biotin from Purebulk plus the scale to measure it 3x a day (capsules have filler in it that gave me GI pain)

    After 6 months he had me stop it. I don’t know why. Think it takes 9 months to start seeing improvement. Some get worse on it, as you can see on the Biotin FB page

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  9. #5
    Distinguished Community Member Cherie's Avatar
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    My neuro is also very keen about Biotin. Even has a share in a compounding pharmacy. He wanted me to start on 100 mg a day and if tolerated work up to 100 mg 3x/day. It gave me very loose stools. Calmed a bit after 4 weeks enough to ramp up to two capsules daily. After three weeks I was able to go up to 3 capsules a day but had to stop that after a week as it really messed with my gut. Not only that but it was giving false high blood sugars on my labs. Apparently Biotin has been used for years as a reagent in certain chemistries and can give false highs with both glucose and thyroid tests potentially leading to prescription of medications that are not needed and could be dangerous. All three of my docs (neuro, PCP and nephrologist) finally asked me to stop it. After three weeks off, I am feeling better and lab values have returned to normal.

    It does seem to help some older people who have had MS for decades to slow progression. Some clinical trials have suggested that there may be some remyelination happening after 8-10 months in a few people. It is not for everybody. I personally felt much worse on it that off it.

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