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Thread: New shingles vaccine (Shingrix) recommended if you're over 50

  1. #1
    Distinguished Community Member agate's Avatar
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    Default New shingles vaccine (Shingrix) recommended if you're over 50

    Even if you've already been vaccinated against shingles (herpes zoster) with Zostavax, it's recommended that people over 50 get the new Shingrix vaccine, which is given in two separate doses.

    If you look at the prescribing instructions, this new vaccine isn't indicated for anyone on an immunosuppressant.

    Also, this recommendation passed by a narrow margin, and the dissenters had concerns about long-term safety issues.

    From NEJM Journal Watch, October 26:





    CDC Advisers Recommend New Herpes Zoster Vaccine over Zostavax

    By Kelly Young

    Edited by Susan Sadoughi, MD, and Richard Saitz, MD, MPH, FACP, DFASAM

    The CDC's Advisory Committee on Immunization Practices voted on Wednesday to recommend use of the newly approved herpes zoster vaccine, Shingrix.

    The inactivated, recombinant subunit, two-dose vaccine was recommended in a 12-to-1 vote for adults aged 50 years and older. The other shingles vaccine on the market, Zostavax, is recommended only for those aged 60 and older.

    Here are some of the data presented to the committee:


    • Shingrix had 97% efficacy in those aged 50–69 and 91% efficacy in older adults.
    • Efficacy was at least 85% at 4 years post-vaccination in patients aged 70 and older.
    • Thirteen people in their 50s — and 11 in their 60s — would need to be vaccinated to prevent one zoster case.
    • Shingrix was more efficacious than Zostavax, particularly for older adults.

    The committee also voted to recommend Shingrix for patients who've previously received Zostavax, with at least 8 weeks between vaccines.

    The vote to recommend Shingrix over Zostavax narrowly passed by 8 to 7. Dissenters expressed concerns about supply, unknown long-term safety issues, and lack of head-to-head comparisons.

    ACIP meeting information (Free)
    Shingrix prescribing information (Free PDF)
    Background: HIV and ID Observations blog post about Shingrix (Free)
    Last edited by agate; 10-26-2017 at 09:55 AM.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

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  3. #2
    Distinguished Community Member BBS1951's Avatar
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    I should talk to PCP about it. I too worry about unknown long term effects.

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