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Thread: Another weird potential MS treatment

  1. #1
    Distinguished Community Member SuzE-Q's Avatar
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    Default Another weird potential MS treatment

    And we thought fecal transplants were weird!

    Acta Parasitol.

    2017 Mar 1;62(1):22-28. doi: 10.1515/ap-2017-0002.

    Trichuris suis secrete products that reduce disease severity in a multiple sclerosis model.

    Hansen CS, Hasseldam H, Bacher IH, Thamsborg SM, Johansen FF, Kringel H.

    Abstract
    Multiple sclerosis is a chronic inflammatory central nervous system (CNS) disease, which affects about 1 in 1000 individuals in the western world. It has been suggested that this relatively high prevalence is linked to a high level of hygiene, i.e. a reduced exposure to various microorganisms, including parasites.

    Parasites are known to employ different immunomodulatory and antiinflammatory strategies, which enable them to evade destruction by the immune system.

    We have investigated the immunomodulation by the swine whipworm, Trichuris suis, by measuring the impact of oral administration of T. suis ova as well as of intraperitoneal administration of T. suis excretory/secretory products on the development and progression of experimental autoimmune encephalomyelitis - an animal model that shares clinical and pathological characteristics with multiple sclerosis.

    Intraperitoneal administration of excretory/secretory products before disease onset, resulted in a significant decrease in disease severity as well as markedly reduced TH1 and TH17 T-cell responses, centrally in the spinal cord as well as in the periphery, i.e. the spleen.

    Thus, parenteral administration of T. suis-derived products results in a skewing of the immune response with a significant impact on disease severity in a CNS inflammatory disease model
    https://www.ncbi.nlm.nih.gov/pubmed/28030334

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  3. #2
    Distinguished Community Member agate's Avatar
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    OK, if these swine whipworms are busily evading destruction by my immune system after they've been injected, and my MS is calming down by some miracle that is connected to the whipworms, what kind of damage are the whipworms doing to me?

    I find it hard to believe that a person with MS could be injected with swine whipworms without some harm resulting but maybe I'm just too easily put off by their name:

    swine whipworms
    They need a different name. There's something about the combination of "swine," "whip" and "worms" that just doesn't have a lot of appeal.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

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  5. #3
    Distinguished Community Member BBS1951's Avatar
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    Too weird. The article looks like something the writers of The Onion would whip up

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  7. #4
    Distinguished Community Member Frog42's Avatar
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    I think I saw something about this several years ago. There is still no way they'd get near me with those nasty things.


    Whatever happens around you, don't take it personally. Nothing other people do is because of you. It is because of themselves. -- Miguel Ruiz

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  9. #5
    Distinguished Community Member agate's Avatar
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    There was this (2013), involving a number of types of worms:

    http://www.sciencedirect.com/science...20751912003153
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

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  11. #6
    Distinguished Community Member Howie's Avatar
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    Unhappy

    I read a book about it.

    H.G. Wells - War of the Worms
    Roswell was a gift.

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  13. #7
    Distinguished Community Member agate's Avatar
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    And there's a Pink Floyd song about it--"Waiting for the Worms" from The Wall.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

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  15. #8
    Distinguished Community Member SalpalSally's Avatar
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    Eekkkkkkkkk!!!!
    Love, Sally


    "The best way out is always through". Robert Frost







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  17. #9
    Distinguished Community Member Lazarus's Avatar
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    I think this is a very good article/hypothesis.

    The obsession people have with antiseptic lives has left us with poor ability to ward off many illnesses. In a tangential way, the cure for peanut butter allergies is to introduce peanut butter in small doses when your kids are children.
    Many articles reflect on the idea that we are cleansing ourselves into the arms of waiting diseases.
    Linda~~~~

    Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"

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