Results 1 to 5 of 5

Thread: (ECTRIMS) Fluoxetine (Prozac) in progressive MS?

  1. #1
    Distinguished Community Member agate's Avatar
    Join Date
    Oct 2006
    Location
    USA
    Posts
    6,730
    Blog Entries
    11

    Default (ECTRIMS) Fluoxetine (Prozac) in progressive MS?

    Presented at the annual ECTRIMS conference in London, September 17, 2016, in the "Late Breaking News" category:

    Quote

    Fluoxetine in progressive multiple sclerosis (FLUOX-PMS)

    M. Cambron1, J. Mostert2, J. Parra3, M. D'hooghe4, G. Nagels4, B. Willekens5, D. Heersema6, J. Debruyne7, W. Van Hecke8, L. Algoed9, N. De Klippel10, E. Fosselle11, G. Laureys12, H. Merckx13, B. Van Wijmeersch14, L. Vanopdenbosch15, W. Verhaegen16, R. Hupperts17, G. Hengstman18, V. Michiels1, A. Van Merhaegen - Wieleman1, J. De Keyser1,6

    1University Hospital Brussels, Brussels, Belgium, 2Rijnstate Hospital, Arnhem, The Netherlands, 3UMCOM, Vrije Universiteit Brussel, Brussels, 4National MS Center Melsbroek, Melsbroek, 5Antwerp University Hospital, Antwerp, Belgium, 6University Medical Center Groningen, Groningen, The Netherlands, 7University Hospital Ghent, Ghent, 8Icometrix, Leuven, 9AZ Marie Middelares Ghent, Ghent, 10Jessa Ziekenhuizen, Hasselt, 11ASZ Aalst, Aalst, 12Maria Hospital, Halle, 13Heilig Hartziekenhuis, Menen, 14MS Centre Overpelt, Overpelt, 15AZ Sint-Jan, Brugge, Belgium, 16Canisius Wilhelmina Hospital, Nijmegen, 17Orbis Medical Center, Sittard, 18Catharina Hospital, Eindhoven, The Netherlands

    Background:

    The progressive phase of multiple sclerosis (MS) is characterized by a widespread axonal degeneration, which leads to a substantial disability in patients and [so far] the currently available disease-modifying treatments [have failed] to stop this degenerative process.

    Since these immunomodulatory treatments do not seem to slow down this process, we suspect that a reduced axonal energy metabolism, axonal glutamate toxicity and reduced cerebral blood flow are involved in this widespread axonal degeneration.

    Fluoxetine [Prozac] has [been] shown to have neuroprotective features and might theoretically reduce axonal degeneration through stimulation of the energy metabolism by enhancing glycogenolysis, increasing the production of Brain Derived Neurotrophic Factor, and dilating cerebral arterioles. This clinical trial aims to test the hypothesis that fluoxetine slows down the progressive phase of MS.

    Methods/design:

    The FLUOX-PMS trial is a multi-center, randomized, controlled and double-blind clinical study. 134 patients with the diagnosis of either secondary or primary progressive MS were treated either by fluoxetine (40 mg daily) or placebo for a total period of 108 weeks.

    The primary endpoint was the time to confirmed disease progression defined as either at least a 20 % increase in the timed 25-Foot Walk or at least a 20 % increase in the 9-Hole Peg Test. Trial Registration Eudra-CT: 2011-003775-11.

    Results:

    Overall 180 patients were screened of whom 134 were randomized to fluoxetine or placebo. Mean age at baseline was 53 years. In total 47.2% of the included patients were female; 24.8% were on classic disease-modifying treatment for MS.

    38.5% of the patients were diagnosed with a primary progressive form of MS.

    Discussion:

    The results of the FLUOX-PMS trial will allow us to assess whether fluoxetine has neuroprotective effects in patients with progressive MS. The results will be presented after all the patients have finished the trial, which is expected by the end of July 2016.
    ___________________
    Disclosure:
    None of the authors had anything to disclose.

    There is also this report in MedPage Today, "Fluoxetine flops as progressive MS therapy":

    http://www.medpagetoday.com/meetingc.../ectrims/60298
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

  2. The following 6 users say "thanks"


  3. #2
    Distinguished Community Member SalpalSally's Avatar
    Join Date
    Oct 2006
    Location
    SWOhio
    Posts
    3,569

    Default

    The Neuro protective features is one of the reasons I have taken Prozac for years.
    Love, Sally


    "The best way out is always through". Robert Frost







  4. The following 4 users say "thanks"


  5. #3
    Distinguished Community Member Lazarus's Avatar
    Join Date
    Oct 2006
    Location
    western MA
    Posts
    992

    Default

    Very very very interesting.
    Thanks for posting this.
    Linda~~~~

    Be the kind of woman that when your feet hit the floor each morning the devil says:"Oh Crap, She's up!"

  6. The following 3 users say "thanks"


  7. #4
    Distinguished Community Member agate's Avatar
    Join Date
    Oct 2006
    Location
    USA
    Posts
    6,730
    Blog Entries
    11

    Default

    Sally, what do you feel Prozac is doing for you? Does it help you in any way you're aware of?

    Or is it something you take for whatever good it might do?

    i don't mean to be snarky here--I take a mega dose of vitamin D3 on that basis. I can't say specifically how it's helping but I keep taking it for whatever good it might be doing.
    MS diagnosed 1980. Avonex 2002-2005. Copaxone 6/07 - 5/10.
    Member of this MS board since 2001.

  8. The following user says "thanks"


  9. #5
    Distinguished Community Member SalpalSally's Avatar
    Join Date
    Oct 2006
    Location
    SWOhio
    Posts
    3,569

    Default

    Quote Originally Posted by agate View Post
    This quote is hidden because you are ignoring this member. Show Quote
    Sally, what do you feel Prozac is doing for you? Does it help you in any way you're aware of?

    Or is it something you take for whatever good it might do?

    i don't mean to be snarky here--I take a mega dose of vitamin D3 on that basis. I can't say specifically how it's helping but I keep taking it for whatever good it might be doing.
    Good question!!!!LOL!
    Love, Sally


    "The best way out is always through". Robert Frost







  10. The following 2 users say "thanks"


Similar Threads

  1. MS patients attending conferences like ECTRIMS?
    By agate in forum Multiple Sclerosis
    Replies: 1
    Last Post: 09-28-2016, 03:09 PM
  2. ECTRIMS 2016 highlights--from MS International Federation
    By agate in forum Multiple Sclerosis
    Replies: 0
    Last Post: 09-23-2016, 07:59 PM
  3. ECTRIMS annual conference in London, September 14-17
    By agate in forum Multiple Sclerosis
    Replies: 4
    Last Post: 09-17-2016, 10:28 AM
  4. Ectrims 2015
    By SuzE-Q in forum Multiple Sclerosis
    Replies: 3
    Last Post: 10-12-2015, 11:26 PM
  5. MS Society Webcast on progressive MS
    By agate in forum Multiple Sclerosis
    Replies: 0
    Last Post: 02-11-2014, 09:05 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  


BTC Inc's Disclaimer and Privacy Policy

The material on this site is for information & support purposes only, and is not a substitute for medical advice provided by a licensed health care provider. Always consult your doctor before trying anything that you find online.