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Thread: Copaxone helps prevent conversion to black holes

  1. #1
    Distinguished Community Member SuzE-Q's Avatar
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    Default Copaxone helps prevent conversion to black holes

    Interesting: copaxone was 3x/week, 40mg dosage:

    http://www.ncbi.nlm.nih.gov/pubmed/25542295

    [paragraphs added for ease of reading]

    J Neurol. 2014 Dec 27.

    Effect of glatiramer acetate three-times weekly on the evolution of new, active multiple sclerosis lesions into T1-hypointense "black holes": a post hoc magnetic resonance imaging analysis.

    Zivadinov R1, Dwyer M, Barkay H, Steinerman JR, Knappertz V, Khan O.

    Abstract
    Conversion of active lesions to black holes has been associated with disability progression in subjects with relapsing-remitting multiple sclerosis (RRMS) and represents a complementary approach to evaluating clinical efficacy. The objective of this study was to assess the conversion of new active magnetic resonance imaging (MRI) lesions, identified 6 months after initiating treatment with glatiramer acetate 40 mg/mL three-times weekly (GA40) or placebo, to T1-hypointense black holes in subjects with RRMS.

    Subjects received GA40 (n = 943) or placebo (n = 461) for 12 months. MRI was obtained at baseline and Months 6 and 12. New lesions were defined as either gadolinium-enhancing T1 or new T2 lesions at Month 6 that were not present at baseline. The adjusted mean numbers of new active lesions at Month 6 converting to black holes at Month 12 were analyzed using a negative binomial model; adjusted proportions of new active lesions at Month 6 converting to black holes at Month 12 were analyzed using a logistic regression model.

    Of 1,292 subjects with complete MRI data, 433 (50.3 %) GA-treated and 247 (57.2 %) placebo-treated subjects developed new lesions at Month 6. Compared with placebo, GA40 significantly reduced the mean number (0.31 versus 0.45; P = .0258) and proportion (15.8 versus 19.6 %; P = .006) of new lesions converting to black holes. GA significantly reduced conversion of new active lesions to black holes, highlighting the ability of GA40 to prevent tissue damage in RRMS.
    Last edited by SuzE-Q; 01-05-2015 at 04:29 PM.

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  3. #2
    Distinguished Community Member Howie's Avatar
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    I am into astronomy, and that's the only black holes I ever think about, but thank you on behalf of others for posting this info.
    Roswell was a gift.

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    Distinguished Community Member SalpalSally's Avatar
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    Oh, that's the newer version of Copaxone. Hmmmmm, time will tell, I guess.

    Thanks SuzE
    Love, Sally


    "The best way out is always through". Robert Frost







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